团队简介：

河北大学药学院乔晓强团队于2025年1月正式组建，团队名称为“药物分析与医药功能材料团队”，现有固定成员13人（教授4人，副教授/副研究员2人，讲师7人），其中硕士生导师13人（含博士生导师2人）。在读博士生9人（其中与临床医学院联合培养1人），硕士研究生39人。团队主要从事高性能新材料的开发制备、疾病特异性标志物发掘与分析以及基于多模态技术构建跨疾病的无创诊疗平台构建等方面科学研究，招收药物化学与分子诊断专业博士生，药学、药物分析学、药物化学、药理学、药剂学、公共卫生等方向硕士生，教授药物分析、药物化学、药理学等核心专业课程。

团队负责人为乔晓强，主要负责团队的重要决策，包括规划学科的长远走向，设计合理的内部协作框架，推动实验条件与信息平台的升级；同时牵头高层次项目的培育与申报，统筹初期资源的合理配置，积极搭建对外学术联络通道。团队其余科研人员依照四大学科方向灵活组队，各组在运行中享有充分的决定权。从研究侧重点的选择，到课题的独立申请与实施，再到经费的自主调剂使用，均由各组自行把控。在成果形成上，论文作者排序、知识产权确权与维护等事宜，亦由各方向组依规商定。

团队成员：

1. 乔晓强，男，1982年生，教授，博士，博导，团队负责人，PI（2011.06入职）

2. 刘会芳，女，1972年生，教授，博士，硕导（1996.09入职）

3. 刘中成，男，1979年生，教授，博士，博导（2008.06入职）

4. 朱 涛，男，1984年生，教授，博士，硕导（2020.10入职）

5. 李 婉，女，1985年生，副教授，博士，硕导（2015.10入职）

6. 赵丹丹，女，1987年生，副研究员，博士，硕导（2023.03入职）

7. 王海燕，女，1993年生，讲师，博士，硕导（2025.01入职）

8. 张厉梅，女，1990年生，讲师，博士，硕导（2025.07入职）

9. 王学丽，女，1988年生，讲师，博士，硕导（2023.01入职）

10. 尹明远，男，1988年生，讲师，博士，硕导（2021.05入职）

11. 郝雪芳，女，1988年生，讲师，博士，硕导（2023.07入职）

12. 顾晓菲，女，1989年生，讲师，博士，硕导（2017.12入职）

13. 高 晗，女，1993年生，讲师，博士，（2026.01入职）

在读博士生

1. 谢沛涓，女，2023级，药物化学与分子诊断

2. 苗雨欣，女，2024级，药物化学与分子诊断

3. 魏 月，女，2025级，药物化学与分子诊断

4. 乔永星，女，2025级，药物化学与分子诊断

5. 夏玲玲，女，2025级，药物化学与分子诊断

6. 齐梦楠，女，2025级，药物化学与分子诊断

7. 王姚俊，男，2024级博士，临床医学（联合培养）

在读硕士生

8. 张玉颖，女，2025级，药学

9. 马晓乔，女，2025级，药学

10. 李璇，女，2025级，药学

11. 施罗欣洁，女，2025级，药学

12. 陈文满，女，2025级，药学

13. 田添茹，女，2025级，药学

14. 马嘉宁，女，2025级，药学

15. 家子洋，男，2025级，药学

16. 谢承烨，男，2025级硕士，药学

17. 安立晶，女，2025级硕士，药学

18. 张奥彤，女，2025级，药学

19. 苏博韬，男，2025级，药学

20. 郭金光，男，2025级，药学

21. 张晓贝，女，2025级，药学

22. 石迎春，女，2025级，药学

23. 王儒雅，女，2025级，药学

24. 吉一凡，女，2025级，药学

25. 武士博，男，2025级，药学

26. 林家旭，女，2025级，公共卫生与预防医学

27. 关新慧，女，2024级，药物分析学

28. 张贺凯，男，2024级，药物分析学

29. 毕舒琪，女，2024级，药学

30. 马佳乐，男，2024级，药学

31. 李京鸽，女，2024级，药理学

32. 陈如笛，女，2024级，药学

33. 艾锦，男，2024级，药学

34. 汪雨涵，男，2024级，药学

35. 于潼，男，2024级硕士，药学

36. 沈熙成，男，2024级硕士，药学

37. 李君淘，女，2024级硕士，药学

38. 黄曼，女，2024级，药物分析学

39. 孙香玉，女，2024级，药物分析学

40. 胡真，女，2024级，药物分析学

41. 武天乐，男，2024级，药学

42. 于仁武，男，2024级，药物化学

43. 王泽宇，男，2024级，药剂学

44. 马文瑶，女，2024级，药剂学

45. 董怡然，女，2024级，公共卫生与预防医学

46. 赵英哲，男，2024级，公共卫生

承担课题：

1. 国家自然科学基金面上项目，多修饰苯乙烯-马来酸纳米刷色谱固定相制备及肿瘤外泌体磷脂动态监测研究，22274035，54万元，2023.01-2026.12，乔晓强

2. 河北省自然科学基金面上项目，细胞外囊泡结合Aβ42寡聚体分析检测平台构建及阿尔茨海默病早期诊断研究，B2026201055，2026.01-2028.12，乔晓强

3. 石家庄市科学技术局驻冀高校重点研发专项，创新中药复方藏茴香肠溶液体胶囊的质量控制技术及药理机制研究，241200153A，20万，2024.1-2026.12，刘中成

4. 中国健康促进基金会横向项目，蛹虫草黄精对动脉粥样硬化发病抑制作用与机制研究，Z089001，10万，2024.4-2025.3，刘中成

5. 中央引导地方科技发展资金项目（科技成果转移转化项目），免疫球蛋白E核酸适配子结构优化修饰及应用，236Z2406G，20万，2023.1-2024.12，刘中成

6. 河北省自然科学基金精准医学联合基金培育项目，促微管聚合蛋白TPPP3通过肥大细胞脱颗粒调控过敏反应的作用与分子机制，H2022201035，2022.1-2024.12，10万，刘中成

7. 北京市永康年健康科技有限责任公司横向项目，蛹虫草黄精对动脉粥样硬化的治疗作用，20万，2022.1-2025.12，刘中成

8. 技术开发横向课题，可降解食品包装材料生物毒性和环境影响评价方法开发，横20250261，8.6万元，2025.11.25-2026.05.25，朱涛

9. 技术开发横向课题，基于低共熔溶剂改性石墨炔的制备及中药材农药残留精准检测技术开发，横20260092，80万元，2026.07.10-2027.10.30，朱涛

10. 中央引导地方科技发展资金项目，手性琥珀酸脱氢酶抑制剂的设计合成及抗真菌活性研究，236Z6505G，2023.01-2025.12，李婉

11. 河北省教育厅青年拔尖项目，外泌体LncRNA高灵敏监测平台构建及其用于肝细胞癌免疫治疗响应预测研究，BJ2026122，10万元，2026.01-2028.12，王海燕

12. 河北省自然科学基金青年项目，基于超声监测-时序释药微针系统的多尺度力学免疫调控新策略用于增强实体瘤治疗，H2026201020，5万元，2026.01-2028.12，张厉梅

13. 河北省教育厅青年基金项目，上转换纳米传感阵列检测食源性致病菌研究，QN2023204，2023.01-2025.12，尹明远

14. 国家自然科学基金青年项目，智能可降解高分子马达响应心梗微环境促血管新生的研究，52503173，30万元，2026.01-2028.12，郝雪芳

14. 河北省自然科学基金青年项目，ROS多级响应性可降解基因/药物共递送系统抑制血管再狭窄的研究，B2025201030，5万元，2025.01-2027.12，郝雪芳

15. 河北省教育厅科学研究项目，ROS适应性基因递送系统用于抑制血管内皮炎性损伤的研究，QN2025303，5万元，2025.01-2027.12，郝雪芳

16. 河北省自然科学基金面上项目，CircALPK2调控心肌细胞内物质运输参与心肌梗死，H2023201029，2023.01-2025.12，赵丹丹

17. 河北省高等学校科学技术研究项目青年基金，CircALPK2调控心肌细胞内钙参与心肌梗死，QN2024005，2023.12-2026.12，赵丹丹

发表论文：

1. Peijuan Xie; Xueli Wang*; Haiyan Wang; Huanxin Xue; Sijia He; Longfei Li; Man Shing Wong*; Xiaoqiang Qiao*. Ultrasensitive extracellular vesicles-associated amyloid-β1-42 oligomers analytical platform for early diagnosis of Alzheimer's disease. Biosensors & Bioelectronics, 2026, 298:118430.

2. Ping Wang; Meijuan Xue; Xinhui Guan; Xiaofei Gu*, Xiaoqiang Qiao*. Preparation of styrene-maleic anhydride copolymer nanobrush chromatographic stationary phase and its application in phospholipid analysis of exosomes. Anal Chim Acta, 2026, 1397:345260.

3. Lin Bai1; Jiacheng Lyu1; Jinwen Feng1; Xiaoqiang Qiao1 et al. Proteomic profiling of pan-cancer plasma study for biomarker discovery. Nature Biomedical Engineering, 2026, 10:16-38.

4. Ruilin Yang; Ping Wang; Xinhui Guan; Xiaofei Gu; Xiaoqiang Qiao*. Exploiting metal-free atom transfer radical polymerization for fabrication of styrene-maleic acid polymer-brush grafting chromatographic stationary phase and its separation performances for phospholipids. Analytical and Bioanalytical Chemistry, 2025, 417:23.

5. Yibo Yan; Ruilin Yang; Yanan Wang; Yinan Wu; Xiaofei Gu; Xiaoqiang Qiao*. Esterified styrene-maleic acid copolymer modified silica as mixed-mode polymer-brush stationary phases for chromatographic separation. Journal of Chromatography A, 2024, 1732:465227.

6. Tingshan Xiao, Yichuan Ma, Ziyang Zhang, Yu Zhao, Yixin Zhang, Xiaohan Zhou, Xueyi Wang, Kun Ge, Junshu Guo, Jinchao Zhang*, Zhenhua Li*, Huifang Liu*. Tailoring therapeutics via a systematic beneficial elements comparison between photosynthetic bacteria-derived OMVs and extruded nanovesicles. Bioactive Materials, 2024, 36, 48-61.

7. Yu Zhao, Yichuan Ma, Qingqing Leng, Qi Zhang, Yuanhang Li, Mengmeng Ji, Hua Yang, Xiaoya Li, Guang Jia, Zhenhua Li*, Huifang Liu*, Jinchao Zhang*. Engineered cell nanovesicle antagonists for androgen deprivation therapy of melanoma. Journal of Colloid and Interface Science, 2025,691:137468.

8. Ziyang Zhang, Yichuan Ma, Zhengxin Yu, Yan Jin, Ying Yang, Mengmeng Ji, Hua Yang, Guang Jia, Jinchao Zhang*; Zhenhua Li*; and Huifang Liu*. Monocyte Backpack Delivery of Engineered MCF-7 Exosomes for the Treatment of Early Stage Type 1 Diabetes, Adv. Healthcare Mater. 2026,15(5), e03453.

9. Qingqing Leng, Zhengxin Yu, Yu Zhao, Yue Shao, Qiuyang Jin, Qiyu Zhao, Ying Yang, Mengmeng Ji, Hua Yang, Lili Ren, Guang Jia, Xueyi Wang, Jinchao Zhang*, Zhenhua Li*, and Huifang Liu*. Targeting pre-metastatic niche with inhalable dendritic cell vesicles to prevent breast cancer lung metastasis, Journal of Nanobiotechnology, 2025, 23, 765.

10. Shushan Mo, Xiaoya Li, Yuanhang Li, Qingqing Leng, Yujing Hu, Jiacong Ai, Junyao Deng, Zhenhua Li, Huifang Liu*, Xueyi Wang*. Mimicking the process from secretory vesicles to organelles in eukaryotic cell evolution by clustering enzyme-liposomes in artiffcial cells. Journal of Colloid and Interface Science, 2025, 696, 137863.

11. Yixin Zhang, Weirun Li, Yingxian Xiao, Li Luo, Jiacong Ai, Shushan Mo, Lanya Li, Junyao Deng, Xueyi Wang, Qishan Li, Yan Zeng, Huifang Liu*, Fei Wang* & Zhenhua Li*. Cardiac reprogramming via transient overexpression of P-glycoprotein alleviates doxorubicin-induced cardiotoxicity in mice and pigs. Nature Communications(2026) https://doi.org/10.1038/s41467-026-71843-9

12. Hui Li, Wenfeng Zhao, Yuyou Deng, Zhongcheng Liu*, Jiameng Li & Shuoqi Tia. LINC00222 regulates FOXO3 to interfere with β-catenin signaling pathway and suppresses prostate cancer progression.Scientific Reports. 2026

13.YiZhao Sun, Heng Li, Juntao Li, YaoJun Wang, Tongyun Long, Zhe Cui, Yanfen Zhang, Zhongcheng Liu*. EGR1 regulates degranulation and mediator release in C48/80-induced pseudo-allergic reactions. Immunologic Research, 2026, 74 (1).

14.Wang, Yaojun; Liu, Zhongcheng*. Comments on "Abrocitinib versus dupilumab: impact on skin barrier function and proteomics in atopic dermatitis".Journal of the American Academy of Dermatology,2026, 94(1)e31-e32

15. Xueran Xiao, Fei Li, Tongyun Long, Feng Xu, Chengyan Zhou, Yanfen Zhang, Zhongcheng Liu*.Tripterygium wilfordii attenuates IgE-mediated type I allergy by regulating Th1/Th2 balance. Advances in Traditional Medicine,2025,25:747-762

16.Xiangyu Liang, Shuoqi Tian, Han Zhang, Shusen Sun , Peixiang Zhang, Jiameng Li, Yong Li, Yanfen Zhang, Zhongcheng Liu*. Efferocytosis: A new star of atherosclerotic plaques reversal. International Immunopharmacology, 2025,146: 113904.

17.Xiangyu Liang, Xiangsheng Li, Shusen Sun, Han Zhang, Bikun Wang, Feng Xu, Yanfen Zhang , Zhongcheng Liu*. Effects and potential mechanisms of Saposhnikovia divaricata (Turcz.) Schischk. On type I allergy and pseudoallergic reactions in vitro and in vivo. Journal of Ethnopharmacology, 2024, 318: 116942.

18. Ziwei Xian, Baokun Tang, Tao Zhu*, Constructing three kinds of porous organic polymers and functionalizing by deep eutectic solvents: the effect of three-dimensional structure and π electronic structure of monomers, Journal of Materials Science, 2024, 59: 6245-6269.

19. Na Li, Baokun Tang, Tao Zhu*, Efficient detection of carbendazim using an electrochemical sensor for a novel NiFeLDH@HsGY-H2/MWCNTs heterostructure with lattice-strain, Analytical Methods, 2024, 16: 6529-6537

20. Yuxuan Zhang, Zhengyue Ma, Meng Yang, Yanmei Chen, Baokun Tang, Tao Zhu*, Preparation of modified graphyne to detect genotoxic impurities in gefitinib: Effects of ionic liquid structures and carbon nanotube composite modes, Microchemical Journal, 2024, 201: 110651

21. Yongrui Liang, Chongzhi Wang and Tao Zhu*, Supramolecular deep eutectic solvent systems-driven interfacial reconstruction of MOF-HsGY heterostructures: Experimental and DFT studies on pesticide selectivity, Applied Surface Science, 2025, 713: 164277

22. Hechen Liu, Chongzhi Wang, Na Li, Baokun Tang, Tao Zhu*, Study on Adsorption of Two Functionalized Conjugated Microporous Polymers: Extraction of Carbendazim and Thiabendazole in Ophiopogon japonicus, Journal of Separation Science, 2025, 48: e70185

23. Shuang Lv, Jialong Zhong, Yilin Xing, Xinyu Song, Wanting Fu, Yonghong Guo*, Tao Zhu*, Zikun Wang*, TfOH/HFIP Cluster-Promoted Direct C-F Bond Activation of Trifluoromethyl Arenes/Alkanes, Journal of Organic Chemistry, 2026, 91(4): 1737-1744

24. Man Huang, Yifeng Wu, Yuxuan Zhang, Baokun Tang, Zikun Wang, Hongyuan Yan, Tao Zhu*, Flexibility-tunable polymeric ionic liquids mediated interface modification of ZIF-67/MWCNTs: triple interfacial mechanisms for selective caffeic acid electrochemical sensing, Talanta, 2026, 309: 129990

25. Xiangyu Sun, Chongzhi Wang, Yuxuan Zhang, Tao Zhu*. Unraveling the synergistic adsorption mechanism via DFT: SUPRADES-functionalized CMPs for highly sensitive detection of thidiazuron. Analytical and Bioanalytical Chemistry, 2026, 418: 2903-2916

26. Man Huang, Yuxuan Zhang, Zikun Wang, Baokun Tang, Hongyuan Yan, Tao Zhu*, Thiol/vinyl-functionalized UiO-66-NH₂-long-branched ester IL composite: DFT-guided electrochemical sensor for sensitive luteolin detection, Microchemical Journal, 2026, 224: 117925

27. Zhen Hu, Yongrui Liang and Tao Zhu*, Dual-functional deep eutectic solvents via ligand exchange: defect engineering and interfacial modification of Co-MOF-74 for electrochemical sensing, Journal of Electroanalytical Chemistry, 2026, 1018: 120431

28. Xinyu Zong; Xiaoyang Li; Shiyu Liu; Guanxuan Jie; Kan Yang; Chunnong Wang; Longfei Li; Fei Cao; Wan Li*. Design,synthesis and SARS‑CoV‑2 main protease inhibitory activities of 2‑arylthiomethyl‑6‑bromoindole derivatives. Molecular diversity, 2025,25,11308.

29. Tianle Wu; Wei Zhang; Quanshui Wang; Renwu Yu; Yi Wang; Jinguang Guo; Longlei Li; Fei Cao; Li Han; Lijuan Wang; Wan Li*. Design and synthesis of thiazolyl hydrazide derivatives as potent antifungal agent. Pest Management Science. 2026.

30. Tianle Wu; Liu Shiyu; Zeng Taining; Yang Zihui; Cao Fei; Li Longfei; You Zhihao*; Li Wan*. Design, synthesis, and fungicidal activity of isoxazoles/isoxazolines containing dihydrobenzofuran.Chemistry & Biodiversity, 2026, 23, e03482.

31. Limei Zhang＃, Huatai Zhu＃, Yuting Ren, Peng Ye, Jiandu Lei, Ferrocene conjugated glutathione consumption for enhanced ferroptosis therapy and chemotherapy, Nano Research, 2025, 18: 94907298.

32. Limei Zhang, Huatai Zhu, Peng Ye, Liyu Zhu, Yuting Ren, Jiandu Lei, Controlled production of liposomes with novel microfluidic membrane emulsification for application of entrapping hydrophilic and lipophilic drugs, Journal of Industrial and Engineering Chemistry, 2024, 131: 470-480.

33. Limei Zhang, Peng Ye, Huatai Zhu, Liyu Zhu, Yuting Ren, Jiandu Lei, Bioinspired and biomimetic strategies for inflammatory bowel disease therapy, J Mater Chem B, 2024, 12: 3614-3635.

34. Limei Zhang, Huatai Zhu, Peng Ye, Yuting Ren, Hongyu Wang, Jiandu Lei,Jing He, Preparation of colon-targeted alginate microspheres loaded with the honokiol-doxorubicin conjugate and their therapeutic effect on colon cancer, Particuology, 2025, 99: 69-79.

35. Kaiwen Jiao, Yingzhe Zhao, Yiran Dong, Lirong Han, Yali Chen*, Xiaoqiang Qiao*, Mingyuan Yin*. Machine learning assisted ratiometric fluorescence sensor array integrated multi-emission signal single sensing element for recognition of diverse tea based on boronic acid functional bimetallic lanthanide metal-organic frameworks. 2026, In Press.

36. Mingyuan Yin*, Kaiwen Jiao, Yiran Dong, Dongfang Qiu, Lirong Han, Linsen Li, Xuelian Hu*, Xiaoqiang Qiao*.Ratiometric fluorescence platform based on luminescence metal-organic frameworks composites for highly sensitive detection of kanamycin in food.Talanta,2026,298:128878.

37. Mingyuan Yin*, Dongfang Qiu, Meiqi Wang, Zedan Wang, Lirong Han, Linsen Li, Jie Tong, Hailiang Nie, Yun Wu*, Xiaoqiang Qiao*.Fluorescence sensor array for highly sensitive pattern recognition of biothiols in food based on tricolor upconversion luminescence metalorganic frameworks.Journal of Nanobiotechnology, 2024, 22:719.

38. Mingyuan Yin*, Zedan Wang, Peijuan Xie, Lirong Han, Linsen Li, Haiyan Wang, Xiaoqiang Qiao*, Qiliang Deng*. Fluorescence sensing platform for Cronobacter sakazakii based on the cationic metal-organic frameworks modified upconversion nanoparticles. Food Control.2023,145:109443.

39.Wenyao Ma; Zeyu Wang; Yifan Ji; Weiwei Gai; Yanping Zhang*; Xuefang Hao*. Biomimetic nanoplatform based on perylene diimide for tumor-specific fluorescence-imaging and drug delivery. Colloids and Surfaces B:Biointerfaces, 2026, 265:115719.

40.Xuefang Hao*; Weiwei Gai; Yanping Zhang; Weitong Zhou; Yakai Feng*. Biomimetic and inflammation-targeted nanoparticles for rheumatoid arthritis therapy via M1-macrophages apoptosis and polarization Materials & Design, 2024, 239:112806.

41.Xuefang Hao*; Weiwei Gai; Yanping Zhang; Dandan Zhao; Weitong Zhou; Yakai Feng*. Peptide functionalized biomimetic gene complexes enhance specificity for vascular endothelial regeneration Colloids and Surfaces B:Biointerfaces, 2024, 241:114020.